A Database of Human Annotated and Predicted Protein Interactions (HAPPI)
The database is a free, open-access, and comprehensive database collection
of computer annotated human protein-protein interactions from public data sources and computational predictions. The database was developed by exhaustively integrating publicly available human protein interaction data from BIND,
OPHID, MINT, IntAct, HPRD, and STRING databases into a data warehouse powered by our Oracle 10g relational database server. In the data warehouse, various types of sequence, structure, pathway, and literature annotation data from
established bioinformatics resources such as NCBI, PubMed, UniProt, HUGO, EBI, PDB were also integrated. Our long-term goal is to develop a
new type of protein interaction database resource for biomedical scientists, who are interested in
evaluating biological significant protein interactions, developing disease pathway models, and identifying disease drug targets or diagnostic biomarkers.
A Database of Healthy Human Individual's Integrated Plasma Proteome (HIP2)
HIP2 database provides comprehensive information on plasma proteins detected from the blood of "healthy" or "normal" individuals (defined as healthy human adults without major life-threatening disease, known genetic diseases, HIV, or inflammation at the time of blood drawing), using different tandem mass spectrometry techniques. The HIP2 database provides protein biologists and clinical biomedical researchers with new opportunities to investigate which proteins may be used for future biomarker research, by comparing plasma proteomics results from patients with diseases such as cancer, neurodegenarative diseases, metabolic diseases, and other genetic disorders. The HIP2 provides first such "background" information on which proteins are expected, with ample peptide sequence as evidence, in health individual's plasma.
