Director, Founding Member
Assistant Professor of Informatics (IU) and Computer Science (Purdue)
Founder, MedeoLinx, LLC, Indianapolis, IN
Email: jakechen@iupui.edu
Research Interests: Translational Systems Biology, Network Biology and Disease, Bio-computing

"Personalized Medicine is about finding cost-effective and individualized biomedical solutions to the diagnosis, monitoring, and treatment of human diseases. In the awakening of evidence-based medicine, particularly in the post-genome era, I believe a systematic, data-driven, quantitative, and holistic approach that integrates molecular level measurements with other clinical observations could bring the maximal technological impacts on future delivery of personalized medicine."

Co-director, Founding Member
Associate Professor of Pathology
Director, Translational Genomics Core, IU School of Medicine
Email:sbadve@iupui.edu
Research Interests: Breast Cancer, Predictive Cancer Biomarkers, Technology Assessment for Clinical Trials

"Many breast cancer clinical trials that I have been associated with would directly benefit from novel detection methods that can better predict risk and treatment response of individuals. Integrative approaches that combine sensitive instruments, 3-D imaging, and computational systems biology methods have a great promise for clinical applications."

Co-director, Founding Member
Professor of Informatics / Biochemistry & Molecular Biology
Director of Bioinformatics Program, IU School of Informatics (Indianapolis Campus)
Email: yqzhou@iupui.edu
Research Area: Protein Folding/Stability, Protein-drug/ligand/peptide/DNA Binding, Macromolecular Complex and Diseases

"We are very interested in developing and applying structural bioinformatics tools to problem-oriented systems biology research. More specifically, we are interested in structure-based prediction and verification of protein-protein, protein-DNA, and protein-DNA interactions implicated in disease networks. Personalized medicine opens up a new world for patient-specific structure-based ligand design, protein design, and protein graft."

Co-director, Founding Member
Assistant Professor of Biochemistry and Molecular Biology
Director, Protein Analysis Research Center, IU School of Medicine
Vice President of Research, Monarch Biosciences, Inc., Indianapolis, IN
Email: muwang@indiana.edu
Research Area: Clinical Proteomics, Molecular Mechanisms of DNA Damage and Repair, Biomarkers for Cancer Drug Resistance

"In translational research, you cannot just talk the talk. A sophisticated theory pales in front of a not-so-elegant solution that delivers the promise. You have to walk the walk here. By putting personalized medicine as the ultimate goal, systems biology research finally can find its real testing ground."